Plasmodium p25 and p28 surface proteins: potential transmission-blocking vaccines.
نویسندگان
چکیده
Plasmodium P25 and P28 Surface Proteins: Potential Transmission-Blocking Vaccines Ajay K. Saxena,* Yimin Wu, and David N. Garboczi School of Life Sciences, Jawaharlal Nehru University, New Mehrauli Road, New Delhi 110067, India; Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 5640 Fishers Lane, Rockville, Maryland 20852; and Structural Biology Section, Laboratory of Immunogenetics, NIAID, NIH, Twinbrook 2, 12441 Parklawn Drive, Rockville, Maryland 20852
منابع مشابه
Transmission blocking potency and immunogenicity of a plant-produced Pvs25-based subunit vaccine against Plasmodium vivax
Malaria transmission blocking (TB) vaccines (TBVs) directed against proteins expressed on the sexual stages of Plasmodium parasites are a potentially effective means to reduce transmission. Antibodies induced by TBVs block parasite development in the mosquito, and thus inhibit transmission to further human hosts. The ookinete surface protein P25 is a primary target for TBV development. Recently...
متن کاملSequence polymorphism in two novel Plasmodium vivax ookinete surface proteins, Pvs25 and Pvs28, that are malaria transmission-blocking vaccine candidates.
BACKGROUND For many malarious regions outside of Africa, development of effective transmission-blocking vaccines will require coverage against both Plasmodium falciparum and P. vivax. Work on P. vivax transmission-blocking vaccines has been hampered by the inability to clone the vaccine candidate genes from this parasite. MATERIALS AND METHODS To search for genes encoding the ookinete surface...
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Malaria transmission blocking vaccines (TBVs) are considered an effective means to control and eventually eliminate malaria. The Pfs25 protein, expressed predominantly on the surface of the sexual and sporogonic stages of Plasmodium falciparum including gametes, zygotes and ookinetes, is one of the primary targets for TBV. It has been demonstrated that plants are an effective, highly scalable s...
متن کاملComplement-mediated lysis of Plasmodium falciparum gametes by malaria-immune human sera is associated with antibodies to the gamete surface antigen Pfs230.
Antibodies to the sexual-stage surface antigens of Plasmodium falciparum, Pfs230 and Pfs48/45, can abolish the infectivity of gametes to mosquitoes; these antigens have been proposed as candidates for inclusion in a malaria transmission-blocking vaccine. One possible mechanism of antibody-mediated transmission blocking is complement-mediated gamete lysis. We have used a panel of human sera from...
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Subunit vaccines are significantly more expensive to produce than traditional vaccines because they are based primarily on recombinant proteins that must be purified from the expression system. Despite the increased cost, subunit vaccines are being developed because they are safe, effective, and can elicit antibodies that confer protection against diseases that are not currently vaccine-prevent...
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ورودعنوان ژورنال:
- Eukaryotic cell
دوره 6 8 شماره
صفحات -
تاریخ انتشار 2007